Actinomycin D

Research use only, not for human use.

A chemotherapy agent that has the ability to inhibit transcription.

A chemotherapy agent that has the ability to inhibit transcription; binds to DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase; can also interfere with DNA replication; leads to the accumulation of transcriptionally active p53 in the nucleus of HeLa, CaSki, and SiHa cells.

Dactinomycin;Actinomycin IV

Cell Cycle/DNA Damage

DNA/RNA Synthesis

DNA/RNA Synthesis

Cancer

——

50-76-0

1255.42

C62H86N12O16

>98% (HPLC)

DMSO: ≥ 27 mg/mL; DMSO: 250 mg/mL (Need ultrasonic); Methanol: 6.2 mg/mL; Methanol: 20 mg/mL (Need ultrasonic); H2O: < 12.5 mg/mL

O=C(N[C@@H]1C(N[C@@H](C(N2[C@]([H])(C(N(CC(N([C@H](C(O[C@@H]1C)=O)C(C)C)C)=O)C)=O)CCC2)=O)C(C)C)=O)C3=C(C(C(C)=C4OC5=C(C(C(N[C@@H]([C@@H](C)O6)C(N[C@H](C(C)C)C(N7CCC[C@@]7([H])C(N(C)CC(N(C)[C@@H](C(C)C)C6=O)=O)=O)=O)=O)=O)=CC=C5C)N=C43)=O)N

Actinomycin D

(-20℃)

With Ice Pack

≥ 2 years