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Actinomycin D

CAS No. 50-76-0

Actinomycin D ( Dactinomycin;Actinomycin IV )

Catalog No. M14735 CAS No. 50-76-0

A chemotherapy agent that has the ability to inhibit transcription.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Actinomycin D
  • Note
    Research use only, not for human use.
  • Brief Description
    A chemotherapy agent that has the ability to inhibit transcription.
  • Description
    A chemotherapy agent that has the ability to inhibit transcription; binds to DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase; can also interfere with DNA replication; leads to the accumulation of transcriptionally active p53 in the nucleus of HeLa, CaSki, and SiHa cells.
  • Synonyms
    Dactinomycin;Actinomycin IV
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    50-76-0
  • Formula Weight
    1255.42
  • Molecular Formula
    C62H86N12O16
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 27 mg/mL; DMSO: 250 mg/mL (Need ultrasonic); Methanol: 6.2 mg/mL; Methanol: 20 mg/mL (Need ultrasonic); H2O: < 12.5 mg/mL
  • SMILES
    O=C(N[C@@H]1C(N[C@@H](C(N2[C@]([H])(C(N(CC(N([C@H](C(O[C@@H]1C)=O)C(C)C)C)=O)C)=O)CCC2)=O)C(C)C)=O)C3=C(C(C(C)=C4OC5=C(C(C(N[C@@H]([C@@H](C)O6)C(N[C@H](C(C)C)C(N7CCC[C@@]7([H])C(N(C)CC(N(C)[C@@H](C(C)C)C6=O)=O)=O)=O)=O)=O)=CC=C5C)N=C43)=O)N
  • Chemical Name
    Actinomycin D

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hietanen S, et al. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8501-6.
2. Sobell HM. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31.
3. Uberti EM, et al. Gynecol Oncol. 2009 Dec;115(3):476-81.
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